Analisis Perhitungan Nilai Biodistribusi Tc-99m Perteknetat Pada Pasien Hipertiroid

Abstract

Background : The distribution value of the Tc-99m radiopharmaceutical in 02 hyperthyroid patients at a Jakarta Hospital was calculated to determine the absorption dose value of the radiopharmaceutical in the thyroid organ. Thyroid scan is a type of examination carried out on patients using a SPECT aircraft equipped with a dual gamma camera detector. The radiopharmaceutical Tc-99m perteknetate is injected into the patient's body via an intravenous line at 3-5 mCi with an imaging time of 15 minutes. Biodistribution determination analysis can be calculated using the ROI technique.

Method : This study is quantitative by collecting data from 10 patients with clinical hyperthyroidism which aims to determine and determine the biodistribution of radiopharmaceutical activity injected into the patient's body.

Result : The results showed that the average biodistribution value of Tc-99m radiopharmaceuticals in the right lobe of the thyroid was greater at 24.59 MBq than the left lobe of the thyroid at 22.96 MBq and the total thyroid biodistribution value was 30.77 MBq. The largest biodistribution was owned by patient number 6 (SR) with a thyroid size of 137.83 MBq, right lobe 68.88 MBq, and left lobe 65.95 MBq while the lowest biodistribution value was in patient number 9 (TBD) with a thyroid size of 8.37 MBq, right lobe 5.23 MBq, left lobe 2.46 MBq.

Conclusion : The average biodistribution of the right lobe is greater than the left lobe in hyperthyroid patients. Radiopharmaceuticals that flow with blood flow cause asymmetrical enlargement of the right lobe so that the distribution of Tc-99m is more in the right lobe.